Toxicology Lab

In BRI’s Toxicology Lab, our technicians analyze tissue samples for total mercury using a Nippon MA-3000 and for lead using our LeadCare® II analyzer. Tissue samples include feathers, fur, blood, muscle, and egg. Our sample processing capabilities include homogenizing samples using a centrifugal mill and freeze drying. Whole blood and post-mortem body fluids can be analyzed for mercury. The toxicology lab also uses XRF testing as a screening tool for other metals, and analyzes skin lightening products for total mercury.

Our lab is certified as a BSL-2 and USDA certified. It has been satisfactorily evaluated during proficiency testing organized by the National Institute for Minamata Disease (NIMD) in collaboration with the United Nations Environmental Programme, Regional Office for Asia and the Pacific (UNEP-ROAP).

Lab Co-Managers:

Contributing Staff:

In-house Lab Capabilities

Mercury and Metals

  • Total mercury determination (using a Nippon direct thermal decomposition mercury analyzer or X-ray Fluorescence instrument)
  • Lead ingestion and blood level determination (radiographic and blood analysis)

Tissue Analysis

  • Tissue moisture determination (using a freeze dryer)
  • Tissue homogenization (using a centrifugal mill)

Wildlife Necropsies

Biosafety Level 2 Capable

Satisfactory NIMD Lab Proficiency Testing Results

Wildlife Health Evaluation

External Capabilities

In addition to its own laboratory capabilities, BRI has established relationships with distinguished labs around the country for specialty work:

Mercury and Metals

  • Dartmouth College
  • Harvard University
  • Texas A&M
  • University of Connecticut
  • USGS – Upper Midwest Water Science Center

Stable Isotopes

  • Boston University
  • Northern Arizona State
  • University of Florida
  • University of Washington

Genetics

  • University of New Hampshire

PAH5

  • University of Connecticut

PFAS and other Organics

  • Texas A&M
  • USEPA – North Carolina
  • Wadsworth Center

Wildlife Health

  • University of Vermont

Analyzing Mercury in Skin Lightening Products

Inorganic mercury is a common ingredient found in skin lightening products (SLPs). The Minamata Convention on Mercury requires that Parties to the Convention phase out the manufacture, import, and export of certain mercury added products including cosmetics with mercury content above 1ppm. BRI’s toxicology lab analyzes skin lightening products for total mercury.

The Global Environment Facility (GEF) funded project Eliminating Mercury Skin Lightening Products aims to reduce the risk of exposure to mercury-added skin lightening products in both humans and the environment. The goal is to eliminate mercury-containing skin lightening products through initiatives that address the main needs for the management of SLPs, which include (but are not limited to) national capacity building on legislation, enforcement, laboratory capabilities, and awareness raising strategies.

BRI is collaborating with the World Health Organization (WHO) for the co-execution of the project which, is implemented by the United Nations Environment Programme (UNEP). For details and updates on project activities, please visit this site.

Minamata Convention and Regional Lab Capacity Building

Laboratory networks for mercury and other contaminant analyses in regional hubs throughout the world, especially in mercury hotspots, will provide important information for the assessment of risk, both to humans and wildlife, in these environments. A Mercury Monitoring Network is important for helping countries that have ratified (or wish to ratify) the Minamata Convention on Mercury to meet their obligations and effectively implement its provisions.

The development of an integrated network of toxicology laboratories will:

  • Help facilitate countries with limited resources to be more efficient in evaluating the effectiveness of the Minamata Convention.
  • Provide a way for countries to coordinate information about mercury in seafood for human and ecological health purposes, and to help build capacity within the region to make independent assessments.
  • Help assist countries with sustainable economic activities related to seafood resources.
  • Provide assistance to build capacity for relevant Ministries to protect human and ecological health.

Networks are in place or are being planned for the following regions:

Caribbean Region

Focal region: Antigua and Barbuda

Highlighted region: Belize

Central Africa

Focal region: Gabon

South America – NW
Focal regions: Colombia, Ecuador, Peru

Indo-Pacific
Focal region: Indonesia

Oceania
Focal region: TBD

Eastern Europe
Focal region: TBD

Sampling Protocols

Photo Credits – BRI